Archive for the ‘Back/lumbar’ Category

Two year Anniversary for Low Back Stem Cells

Monday, September 26th, 2011

low back stem cells

JS is a patient we treated two years ago with the Regenexx-C procedure which involved injecting his own cultured stem cells into his bulging low back disc. Before we tried this, he was being treated several times a year with epidural injections, which gave him some relief, but this was more of a stop gap measure to manage his disc bulge rather than a fix. After his stem cell injection, the patient had great results as shown on his MRI, with a dramatic reduction in his low back disc bulge size. I got this unsolicited text on Friday, so I thought I’d share it:

Dr. Centeno, it is [JS].  Sorry to invade your space, but today is the 2 year anniversary of the last procedure I had.  I want tell you that my life is a different life. I live today free of pain killers, & only need to medicate rarely. You have truly changed my entire family’s lives.  I live a normal life that j never thought I would see. My family thanks you for continuing to push that envelope & never giving up. Thanks to you & your entire wonderful team.

While we can’t fix everyone with a low back disc bulge and our procedure isn’t magic in that it has a success and failure rate, it’s messages like this from patients that make us doctors smile.

Share

Low Back Facet Joints and Stem Cells?

Friday, September 23rd, 2011

low back facet joints stem cells

Can stem cells be used to help low back facet joint pain? The answer is that it depends. If the facet joint was damaged due to trauma (more common with neck facet joints) then we’ve seen good results. However, much of low back facet pain is degenerative and thus due to longstanding wear forces. To review, the facets in the low back are the joints that help to connect the back of the vertebrae at each level. The normal curvature in the back helps distribute the load of the body evenly between the front of the spine (discs) and the back of the spine (facet joints). If you look at the drawing above, notice the facet joints are in the back of the spine (front is to the left in this picture).  Recently I examined a patient in clinic who had 6 months of relief from traditional steroid facet injections that were performed because his MRI showed swollen facet joints. This worked very well for awhile, but then the pain came back with a vengeance. Why? Well the first reason is simple, while steroids are potent anti-inflammatories, they also chew up cartilage, so when the anti-inflammatory effect wore off, the facet joints were likely worse off because of the steroid. The second reason the pain returned may not be as readily apparent, but gets down to the basics of our orthopedics 2.0 approach (see our practice’s e-book for more information). Notice above that this patient’s spine looks more like the one on the right, where there’s a high sacral angle. This means that his sacrum (the triangle at the bottom of the spine) is oriented more horizontally than most. This can happen when the psoas muscles are too tight or for any number of other reasons. As a result, his spine bends backward on itself, trying to compensate. This causes more pressure on the facet joints which are wearing out. So if we place magic stem cells in these facet joints, even if they work to shore up his degenerating cartilage, the patient’s pain will just come back because we did nothing to help his high sacral angle. While we’re just getting started with this patient, the implications of his bio-mechanics on what we can do for him with stem cells is clear. In order to save a joint not only do you need to know how to help that joint, but you also need to know how it got that way in the first place.

 

Share

Low Back pain causing Knee Pain?

Friday, September 16th, 2011

low back knee pain

Low Back pain causing Knee Pain? One of the more common misdiagnoses we see on a day to day basis is a patient with minimal back pain and knee pain, but whose knee pain is really being caused by a pinched nerve in the back. What? Is it possible that a patient with a pinched nerve in the back doesn’t have much back pain? Isn’t it the knee causing the back to be sore? Sometimes. The nerves in the low back go to the legs, so if I were to reach into your back right now and pinch a nerve, you’d feel it somewhere in your thigh, knee, leg, or foot and likely not much in your low back. Most doctors have been tranined to diagnose picnhed nerves in the back only when there’s numbness or tingling down the leg (sciatica), but to ignore the back when there’s just pain someplace in the leg. As an example, take this patient of Dr. Hanson’s who was seen yesterday. The patient had severe arthritis of both knees and was deemed a candidate for a Regenexx-AD stem cell procedure because of his displaced meniscus tissue from prior meniscus “chop” surgeries. He denied any back issues at the time. He obtained only minimal improvement with the stem cell procedure for the knee arthritis, so Dr. Hanson went digging deeper. Turns out the patient did have some off/on back issues through the years and sure enough, his exam and later his MRI showed that he had an L5-S1 disc bulge pressing on a spinal nerve. Dr. Hanson treated the disc bulge with the Regenexx-PL-Disc procedure and now his knee pain is 60% better as a result of the low back treatment. We see this all the time. As a result, we can’t stress enough that a thorough vetting of your low back is critical if you have hip, knee, ankle, or foot pain. As another example, read this blog post about a  rock climber who was told he had severe intractable plantar fascititis but really had a low back problem. Another patient that comes to mind was a late 30′s mother of two who was told she needed a hip replacement because her MRI showed a congenitally short hip socket and mild arthritis, but who really had a disc bulge irritating the S1 nerve. We treated her S1 nerve problem with the Regenexx-PL-Disc procedure and her hip pain went away. You might be saying to yourself about now, “But my doctor said I have ___ arthritis (insert hip, knee, ankle in the blank) so that must be what’s causing my pain!” While your arthritis may need to be treated as well, it may not be the main cause of why you hurt. Recent research showing that some patients still have severe knee pain after a knee replacement only strengthens the argument that we need to be doing more to identify the source of knee pain before major surgery to chop out the joint. To learn more about the science behind these concepts, see our practice’s e-book, Orthopedics 2.0. For a shorter discussion of the science, see this post where recent research connects nerve problems with arthritic pain.

Share

Why Back Surgery Backfires

Friday, July 22nd, 2011

Low Back Surgery Alternative

Interesting article this week posted at MSNBC.com about a recent study of patients undergoing low back surgery. The study demonstrated that of those patients who opted for back surgery, only 26% went back to work compared to 67% of the patients who didn’t get surgery. There was also an increase in the use of pain medications after surgery. As we have always said, for a very few patients, low back surgery can be a godsend. However, that’s only about 1-2 in 10 (IMHO) of the patients currently undergoing back surgery. The problem with conventional low back surgery is that it either cuts out parts of the disc or fuses together vertebral segments that were built to move. By taking out parts of the disc, the surgery weakens the disc and makes it more likely to fail. To understand this phenomenon, think of the low back disc like a bicycle tire. As illustrated above, the thick outer rubber tube can develop cracks and tears which let the inner tube bulge out (just like a disc bulge). Rather than fixing the cracked outer rubber part, our current surgical approach just lops off a piece of the outer rubber tube (the part pressing on a nerve), making the tire less durable and more likely to fail. Low back surgery does the same thing, no matter if it’s through a scalpel or a laser. In the case of the low back, the outer rubber tube is the disc annulus (outer part of the disc) and the inner tube is the nucleus pulposis (inner rubbery gel part). Is there a better way? We believe in either injecting substances to help the disc area heal (like the Regenexx-PL-Disc procedure) or to help heal the cracks (like the Regenexx-C-Disc stem cell procedure). We’ve seen significant improvement in low back discs by simply injecting the patient’s own specially grown stem cells into these tears. The upshot? Looking at the bicycle example, it’s no wonder why disc surgery often fails miserably.

Share

SI Joint Pain after Low Back Fusion

Tuesday, July 12th, 2011

low back fusion si joint pain

Low back fusions are a big problem. While a few patients who get their back fused really need the procedure to control serious instability, most patients get their back fused to help control pain. Recent controversies surrounding things like BMP drugs to promote fusion (which cause sterility in men), the fact that we American doctors fuse far too many low backs, and the complications associated with low back fusion surgery all make the topic important if you’re considering spinal fusion surgery. For those patients who decide on a low back fusion because of pain, a recent study demonstrated that in many patients, the SI joint is being made painful by fusing the low back. Why? Your back bones are built to move. When one of them is artificially stopped from normal motion by fusion, the adjacent levels get overloaded, leading these levels to become degenerated at a faster pace. In one study, 16.5% of the patients who had their low back fused at 5 years and about 1/3 of patients at 10 years needed additional surgery to correct spinal degeneration caused by the fusion.The SI joint study above demonstrated the same phenomenon, but with the next joint down from the lumbar spine, which is the SI joint. This has become such a common area of pain in post fusion low back patients in our practice that it’s almost automatic that someone who has had their low back fused and who is experiencing pain in the back of the hip will undergo an interventional pain (read injection) work-up for SI joint syndrome. Just this last week I saw an unfortunate patient who had a 5 level low back fusion and ended up with more pain than before the fusion, this time above and below the fusion. The upshot? If there’s another way to manage your low back pain, don’t get your low back fused! Artificially stopping normal motion has unintended consequences and complications.

Share

More stem cell disc updates…

Monday, July 11th, 2011

stem cell disc

I’ve blogged on NQ in 2010, after she received a Regenexx-C disc procedure and reported very good resolution of her leg pain which was being caused by by a L5-S1 disc bulge. At that time, I posted some sagittal MRI films (side view) showing an improved disc bulge after the stem cell disc procedure. More recently, I reviewed her follow-up films taken this month (14 months after the disc stem cell procedure) and saw again that her stem cell treated disc still looks better. This time I compared the axial films (above) which are a top down look at the disc. In the Sep 2009 films, note the white dashed line that outlines the disc bulge as it pushes into the spinal canal and crowds out the descending S1 nerves. After the disc stem cell treatment, there’s much less of a disc bulge in the spinal canal (Jun 2011). I also had the opportunity to follow up on her clinic records and confirmed that her sciatic symptoms are still much better. While all patients treated with the Regenexx-C disc procedure may not get these same results, we were able to help NQ’s disc without surgery, but simply a highly accurate injection of her own specially processed stem cells into her low back disc.

Share

Disc Stem Cell Success, More of the Story Unfolds

Tuesday, June 28th, 2011

disc stem cell treatment

JS is a long-standing patient who we were managing with steroid epidurals for years. He had a large L5-S1 disc bulge and ultimately decided to undergo a Regenexx-C disc procedure. He did very well, reporting dramatically improved function, a decrease in his medications, as well as being able to sit longer and do thing like Jet Ski. He also hasn’t needed an epidural since 2009, after years of needing them several times a year (usually before tax season, as he works as an accountant). His pre-op disc stem cell injection MRI was dramatic in that it demonstrated a huge disc bulge, ballooning out from the L5-S1 disc. After he reported his dramatic success with the disc stem cell injection, we did obtain a follow-up MRI, but I was frankly too busy to spend time with the before/after films. Yesterday, while getting our disc stem cell data together for publication, I finally reviewed the films. Since they are as impressive as his reported clinical result, I thought they were worth sharing. The pre stem cell injection films are on the left, with the 5 month post stem cell injection films on the right. Note that the before side view (left upper image) has a large “beer belly” in the back of the lowest disc (L5-S1-in the red dashed circle). The before stem cell top view (left lower image) shows the same large bulge in another view (red dashed line). The matched after films on the right show that in both side view (right upper image) and top down view (right lower image), the disc bulge has all but disappeared (yellow dashed line).

Can every patient that undergoes the Regenexx-C stem cell procedure for the disc expect these dramatic results? NO. Here’s a link to a disc stem cell patient that didn’t get these same results. However, since this outcome was achieved with a disc stem cell injection and without surgically removing pieces of the disc, we’re very encouraged that this much less invasive procedure is clearly a next generation option for appropriately vetted patients considering disc surgery.

Share

More BMP Problems: Now the Low Back Fusion Drug is Linked to Sterility in Men

Saturday, May 28th, 2011

low back fusion complications side effects

I have blogged on BMP’s before. These drugs are very, very potent artificial growth factors that stimulate bone production. They are administered at very high doses in cases of low back fusion and have had links to cancer and nerve root irritation. The goal of using this drug with a low back fusion is to cause the bone placed in the fusion area to heal faster and better. However, now a MedPage Today story highlights that complications were withheld by the drug’s manufacturer and that BMP’s are associated with higher rates of male sterility. Why? The body uses very small amounts of these bone morphogenic proteins (BMP’s) to help modulate how it makes bone. In the 1990′s, researchers noted that giving huge doses of lab created BMP’s would cause more bone formation. When you put this ability to make new bone together with the fact that some low back fusion surgeries fail because of too little bone growth, it made some sense to add BMP’s to low back fusion surgeries. However, as soon as the drugs began to be used, we saw serious nerve root irritation syndromes in our patients receiving low back fusions. Since nerves would normally be no stranger to BMP’s as they occur naturally in the body, this meant that either the BMP’s being used were foreign (possible) or that the doses being used were way too much. As a result of treating these patients, it’s not surprising to us that using massive amounts of a lab created growth factor may cause other problems. When we first began thinking about the best ways to culture stem cells in 2005, we avoided these problems in our Regenexx-C stem cell injection procedure by staying away from the lab created growth factors. For example, in most all stem cell culture procedures, large amounts of artificial growth factors are used to help stimulate the cells to grow. However, we were able to avoid exposing our patients to these substances by using the naturally occurring growth factors from the patient’s own blood platelets. The upshot? If you have a low back fusion planned and are male and have yet to have kids, you may want to ask if BMP’s will be used and skip the heavy helping of pharma derived, lab created super goo.

Share

Low Back Stem Cell Long-term Success

Thursday, May 19th, 2011

low back stem cell treatment

KG is now a model in her early 40′s who had a failed low back surgery. Several years ago, her chronic sciatica was being managed by us with epidural steroid injections. These epidural shots would give her a few weeks to months of relief, but nothing long-term. We also had a concern about managing her this way due to the serious side effects of steroid anti-inflammatory use. Her other options were to stay on high dose nonsteroidal anti-inflammatories (NSAID’s like Celebrex), but we now know these drugs can cause heart problems. Instead she underwent the Regenexx-C disc procedure in 2008 for a disc bulge, which promptly resolved after we placed her own stem cells in her low back disc. We got this e-mail from her this week:

“I wanted to touch base with you, to tell you that I’m feeling great! My back, my spine, is wonderful. It seems to be getting better all the time. I’m sleeping, moving, functioning very well. I cannot thank you enough for what you and your staff has done for me.”

It’s great to hear that KG is doing well after a single injection of her own stem cells into her low back disc bulge 2.5+ years ago. We’re happy that was able able to dodge the bullet of another invasive back surgery! It’s important to know that all patients don’t get these same results.

Share

Update on the Rock Climber who had Failed PRP Achilles Tendon Injections

Tuesday, May 17th, 2011

ankle prp tendon injections

I examined the rock climber in clinic this past week who had failed PRP injections into his Achilles tendons. After seeing another provider in an orthopedic practice and getting 5-6 PRP injections, he was still unable to run due to heel pain. The reason? Nobody looked at whether a pinched nerve in his low back might be causing his Achilles tendon pain. After seeing him this week for his third Regenexx-PL-Disc procedure, he’s now back to running with his right ankle completely pain free and his left well on the way. How could his low back cause his Achilles tendon problems? For a more complete explanation, see our medical practice’s book, Orthopedics 2.0. However, briefly, an irritated S1 nerve in the low back can mimic an Achilles tendon problem. First, if you look at the dermatome map above and follow where the S1 low back spinal nerve goes, it travels down toward the back of the leg and heel. So if I could reach in and pinch your S1 back nerve, you would feel it in the back of your heel. Second, the nerve also powers the calf muscle, so an irritated S1 nerve in the back causes a dysfunctional calf muscle. This muscle is attached to the Achilles tendon, which then begins to develop issues. We’ll continue to follow YSL, but it’s great to see that a more comprehensive look at his Achilles tendon problems beyond just PRP injections in his Achilles tendons is helping him get back to what he loves to do!

Share