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Blogging from the Caymans, Amazing Results, and Banana Republic Clinics

POSTED ON IN Latest News BY Chris Centeno

panama stem cell clinic

Once every four months, I travel down to our licensed, Grand Cayman advanced stem cell practice site. Today I saw a patient with amazing results in her hip. I also communicated with a patient who was confused as to how to measure the quality of a stem cell procedure. That launched the mantra above: “What+Where+How.” Let me explain.

Why Do I Travel Down to Grand Cayman?

The Grand Cayman site is permitted to culture stem cells to bigger numbers. This affords us several things we can’t do in the U.S. These are the following:

  1. Much higher stem cell dose
  2. Injections in many areas
  3. The ability to save cells in cryo for future use
  4. Specific conditioning protocols in culture that can tailor a therapy for a specific clinical need

The video below explains some of these differences as well:

As far as much higher cell dose, since the cells are expanded in number in culture, we can generally inject at least 100X more stem cells. The good news is that for the vast majority of patient conditions, this isn’t needed. However, for severe hip arthritis, disc bulges pressing on nerves, and a few other issues, having more cells is helpful.

In addition, having more cells allows many, many areas to be treated at once. For example, we can place one to two million mesenchymal stem cells in platelet rich plasma and treat many tendons with pain. At that dose, we’re still at much higher levels of stem cells than same-day, bone marrow concentrate. We can also treat multiple joints at once. So if a patient comes to us with 6–7 areas to treat that need stem cells, the Caymans is a good option.

In Grand Cayman, we can also save cells for future use. We do this with several NFL athletes who can store cells at their younger biologic age and then use them later in their careers. It also allows a patient to undergo a single bone marrow aspirate and then to be seen many times for multiple different issues with stem cells “in the bank.”

Finally, we can deploy specific conditioning protocols in culture to tailor cells to a specific therapy. For example, using culture conditions that mimic the harsh conditions in a degenerative disc or adding in adjuvants to push stem cells toward cartilage. In summary, the cells can be customized for a specific clinical purpose.

The Amazing Cayman Result

I saw a patient with severe hip arthritis today, and her post-injection MRI floored me. We have been slowly closing in on how to best treat these patients over the last few years. While patients with mild to moderate hip arthritis have always done well, severe hip arthritis almost seems like a different disease. One of the differences between severe hip and knee arthritis is the frequent involvement of the bone.

A few years ago, we began to add in certain elements to our treatment of severe hip arthritis that seemed to improve outcome. One of those keys to successful treatment was aggressively treating the bone with precise fluoro-guided stem cell injections. However, we believed that this was only possible in patients who had MRI evidence of bone marrow lesions (see the video above for more info on these lesions), but that if they had cysts (which represent dead bone) no amount of treatment would help the bone regenerate. That changed today.

hip avn stem cell procedure

This patient’s MRI is above. The cysts are the white circular or oval areas in the otherwise dark bones in the “before” images on the left. I have included the coronal (front view), sagittal (side view), and axial (top view) images. One year after I precisely injected the cysts, the right images show fewer, smaller, filled in, or disappeared cysts. I have never seen this before in 13 years of treating hips.

Why is this result a game changer? Most hips that have severe arthritis have these cysts that represent dead bone. If we can heal them with an injection, it means we can successfully treat many more severe hip arthritis patients.

How is this advanced procedure performed? See Dr. Bashir (now in Miami) perform this procedure in the video below:

The Banana Republic Stem Cell Clinic

This week I was contacted by a patient considering a banana republic stem cell clinic because we were too full at the Grand Cayman clinic. Sometimes it’s hard to relay to patients why what we do is VERY different than clinics in Panama, Mexico, or elsewhere. Hence, I came up with the above mantra: “What+Where+How.” Let me explain.

Luckily, I had a patient today who was a retired airline pilot who had a friend who went to this particular banana republic clinic. He paid 25K (more than the cost of treatment at our licensed Grand Cayman clinic) to get culture-expanded fetal cells injected via IV and into his knee. The knee injection was blind without guidance. In addition, there was no real candidacy or targeting process as the local banana republic doctor didn’t need to see his MRI. His friend had to bring it up on his phone to show the doctor! Hence, everyone was magically a great candidate, and the doctor wasn’t attempting to inject stem cells into specific areas in need of therapy.

Hence, I came up with the following mantra:

  1. What? This means what’s injected. In this case, fetal stem cells. While these may work for arthritis, we have ZERO published clinical evidence that they are effective. In addition, this type of therapy adds additional risk.
  2. Where? You can see from my case above, I specifically injected this patient’s bone cysts under very precise X-ray guidance as well as her joint, labrum, and tendons (see the Dr. Bashir video). That whole procedure took hours to do correctly. At the banana republic stem cell clinic? A blind injection taking minutes without any documentation they actually got anywhere close to the knee joint, let alone any specific structure in the knee.
  3. How? Again, you need to inject these cells using fluoroscopy and/or ultrasound guidance. Doing less than that is BELOW the standard of care.

Why would a clinic charge 25K for a blind knee injection? The problem for all banana republic clinics or those in Mexico is that it’s almost impossible to bring in US licensed and trained physicians. In the Caribbean, the small islands welcome US physicians because they have a chronic physician specialist shortage.

Why can’t US physicians get a medical license in these countries? Banana republics have loads of local docs who have created laws to keep the US docs out. Why? How can a banana republic doctor compete with a US doctor? The wealthy in these countries would all want US physicians as they believe there is a dramatic quality difference in everything from US-educated business people to attorneys to doctors.

The other issue in banana republics? You can’t find interventional pain physicians who can use fluoroscopy and ultrasound. In the U.S., it’s hard enough to find doctors who know interventional orthopedics; in a banana republic, this just doesn’t exist. To learn more about the differences between simple joint injections and advanced interventional orthopedics, see my video below:

Finally, the banana republic and Mexico clinics are not owned and operated by physicians, but businessmen. While physicians like myself would never put up with a doctor performing a blind, below-the-standard-of-care knee injection, the business guys who own these clinics don’t know the difference. However, now you do as well.

The upshot? At the end of the day, the Cayman clinic is the world’s most advanced orthopedic stem cell-culture facility. Why? While there are a few clinics around the world where you can also find culture-expanded stem cells, nobody is practicing minimally invasive interventional orthopedics. What you’ll get is a simple, often blind, joint injection by the local yocal doctor. Certainly, the type of advanced hip arthritis procedure you see above would never be possible at a Mexican or banana republic clinic. So as I always say, do your homework! The Cayman clinic usually has a longer wait time because all the physicians are US doctors who are part of our elite provider network, but you get what you pay and wait for!

The Regenexx-C procedure is not approved by the USFDA and is only offered in countries via license where culture-expanded autologous cells are permitted via local regulations. 


    Albert says

    On your webpage, you have a registry of outcomes for the same day stem cell treatments. I know you maintain outcome data for patients treated with cultured stem cells (which as you stated above can use 100x or more cells). Is there any reason why you don't publish results for the treatments that use cultured stem cells? At least for the knees, you must have done 100s of cases by now.


    Chris Centeno says

    Albert, we have that data. The issue is that the two datasets can't be compared directly as much more severe knee patients are seen in the Caymans. The last time we compared these datasets the Caymans had about a 15% greater response rate in that group of patients.


    Susan says

    Let's hope so - I had my BMA 2.5 weeks ago and am going down in May for re-injection with Dr. Newton. However, I'd like the post-procedure protocol to be more clear. I understand I'll wear a brace on both knees for six weeks but are you able to exercise if it doesn't cause pain? Obviously, what the patient does after re-injection affects long-term success. Thanks so much


    Chris Centeno says

    Susan, there are rehab/post-op protocols for each procedure. The Cayman clinic can get you those handouts.


    Dane says

    Dr. Centeno,
    Exactly one year ago to this day you did my bone marrow aspiration in Grand Cayman, then Dr. Pitts did my knee, spine and shoulder treatments a month later. I'm now doing much better. There's a beach park in Seattle (where I live) that has a 188 step stair climb... I recently started jogging it and climbing skipping steps. The knees have been handling it pretty well, although it's revealed how out of shape I am from spending nearly 2 years in pain unable to workout. I'm sure that will change though, it's good to feel my lungs and muscles burning again without my knees screaming at me the next day. I still have some patellar tendon pain and am heading back in a couple months to see Dr. Schultz, hopefully we can knock it out of the park (maybe grow some more cartilage too)! I'm thankful for the work you're doing, the excellent work by Dr. Pitts, and look forward to meeting Dr. Schultz in a couple months!


    Regenexx Team says


    Jogging up and skipping step sup a 188 stair climb is an amazing visual! So glad to hear you're doing so well!


    Jeff Dejax says

    I am 51, and have severe problems with one knee and moderate problems of the same nature with the other. I have been diving into all the info I can find on torn/worn meniscus and torn/stretched/lax MCL. I paid for my own MRI two weeks ago, and am
    now trying to decide what to do next. I’ve always played hockey, ridden horses, hunted & hiked, played basketball & baseball. Now I can hardly walk and can’t straighten one leg. My medical doctor says there’s nothing to do except tough it out until total knee replacement. ANY input from those of you reading this would be very much appreciated. My email is :[email protected]


    Regenexx Team says

    Great to hear your Doctor did not suggest a knee replacement at 51, as the results for younger active people are comparatively poor and the need for revisions can be too numerous. Thankfully, it's often possible to avoid knee replacement altogether. Please see: and and and and and and and If you'd like to see if you would be a Candidate, please submit the Are You a Candidate form here:


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    About the Author

    Chris Centeno

    Christopher J. Centeno, M.D. is an international expert and specialist in regenerative medicine and the clinical use of mesenchymal stem cells in orthopedics. He is board certified in physical medicine as well as rehabilitation and in pain management through The American Board of Physical Medicine and Rehabilitation.…

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