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Can You Defeat Your Obesity Genes with Exercise?

POSTED ON IN Latest News BY Chris Centeno


obesity genesWhile our genes may determine if we have a predisposition to be fat, I live in the world’s fittest city. Inside the Boulder, Colorado, bubble, as it’s called, obesity of the type seen elsewhere is rare. Hence, the new conclusions from a new research study aren’t surprising, as it shows that exercise levels may trump genes when it comes to weight gain, particularly as we age. Before we delve into the study, let’s review genetics versus our lifestyle as it relates to obesity.

Genetics vs. Lifestyle: Which Causes Obesity?

You’ve probably heard many people blame their excess weight on their genetics, and the fact is, there is a great deal of truth to it. Many of us really are genetically predisposed to obesity, meaning we carry “obesity genes” passed down from our parents and their parents and so on. Not only do our genes determine all the things we learned about in basic biology, such as eye color, body structure, skin color, and so on, but they also determine our risk for diseases (e.g., arthritis, dementia, certain types of cancer, etc.). However, while we can’t change genetic attributes such as eye color, we can adjust our lifestyle to minimize our risk for diseases or conditions we are genetically prone to, such as obesity.

There’s a whole field of study, which I’ve covered on this blog a few times, dedicated to how environmental influences can alter our genes. This is called epigenetics. Environmental influences can include anything from living in a toxic environment (one study found living close to highways increased the risk of Alzheimer’s dementia for example) to smoking, which is well known to cause cancer, to consuming junk food (e.g., fast food, processed carbs, sugar-laden snacks, etc.) as part of a regular diet, which we know leads to metabolic syndrome and obesity. Add a genetic predisposition for Alzheimer’s, cancer, or obesity on top of these poor lifestyle choices, and it would be almost impossible to dodge the bullet.

Forego the poor lifestyle choices, on the other hand, and replace them with positive choices, and some studies have shown that not only does this, understandably, lower your risk of these conditions, but in some cases, it actually modifies the genetic predisposition as well. Let’s review our feature study on how one lifestyle choice—exercise—seems to modify “obesity genes,” or the genetic predisposition for obesity.

How Exercise Impacts the Genetic Risk for Obesity

The new study consisted of over 8,000 postmenopausal women separated into multiple groups depending on activity level (from high activity to sedentary) and age. The intent was to examine the effect of exercise on those at a genetic risk for obesity, specifically whether or not genetic risk could be modified by exercise. Age was also an indicator analyzed in the study. Researchers found that exercise reduced the genetic risk of obesity in those in the high activity group. Interestingly, the age group this finding was most pronounced in was the age 70 or older participants, the oldest age group. This may suggest that the longer you exercise as you age, the more impact exercise has on your genetic risk for obesity.

More Studies on How Lifestyle Choices, Such as Exercise, Impact our Genes

I’ve covered a lot of studies recently on aging and exercise, and the constant stream of research on the topic continues to support what I say all the time: while you may have an advantage the earlier you start and maintain an active lifestyle, it’s still never too late to start. In fact, today’s study isn’t the first I’ve covered on genetics and aging being impacted by exercise. A study a couple of years ago found that exercise altered six specific genes that were associated with muscle repair and maintenance. Again, interestingly, the effects were most pronounced in older subjects. Here are a few more fascinating studies on genetics worth reviewing:

The upshot? Think of your genes as the rough outline for a life story. You can either fill in the details along the lines the story dictates or you can rewrite it by making better choices. In this case, exercise can reauthor your genetic story.



    Marguerite Eustace says

    Are websites that offer to test saliva for DNA genetics worth trying to identify risk factors for disease as I wonder if they are reliable?


    Regenexx Team says


    Please see:


    Valerie Bell says

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    Regenexx Team says


    Wonderful news - We'll share with Dr. Movva!


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    About the Author

    Chris Centeno

    Christopher J. Centeno, M.D. is an international expert and specialist in regenerative medicine and the clinical use of mesenchymal stem cells in orthopedics. He is board certified in physical medicine as well as rehabilitation and in pain management through The American Board of Physical Medicine and Rehabilitation.…

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