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Front Inside Knee Pain Caused by a Loose Ligament

POSTED ON IN Knee Ligament/tendon Videos BY Chris Centeno

front inside knee pain


This past week, while seeing patients in Grand Cayman, I saw a woman who had gotten some relief from a first stem cell treatment for front inside knee pain, but she wanted more. What was interesting was that her remaining pain in this area of the knee seemed to be caused by a loose ACL ligament. How could a ligament in the middle of the knee have anything to do with why the inside of the front of her knee hurt?

What Is the ACL Ligament?

The anterior cruciate ligament (ACL) lives in the center of the knee and prevents the tibia (the larger lower-leg bone) from shifting forward. The ACL also stabilizes the tibia during rotational movements, and when the ACL becomes loose, it can cause rotational instability in the tibia, also causing pain.

Most physicians who examine the ACL are looking for catastrophic instability that would require surgery. Hence, what often gets missed are loose ligaments that over time can lead to problems. In this patient, her traditional drawer test was normal, but a second, less-well-known ACL test showed issues. So how could this second positive test relate to front inside knee pain even though most physicians would have said her ACL test was normal?

The Drawer Test Shouldn’t Be the Only Test in Front Inside Knee Pain

When a patient has an unstable knee, providers typically will only do what’s called a drawer test, which looks at the anterior stability of the tibia, and doesn’t test the rotational stability. It’s possible that a patient could have rotational instability without anterior instability, so a normal result on a drawer test shouldn’t lead the provider to conclude that the knee is fully stable.

This was what happened with a patient of mine, whose case I highlighted in the video below. She’d had a normal drawer test, so when I pulled the tibia forward, it seemed to be fine; however, when I took it a step further and rotated the tibia, it was unstable compared to her normal side. She had initially injured the ligament in a ski injury, and the rotational instability from this old injury ended up causing some serious issues for her.

Loose ACL with Rotational Instability Leads to Knee Meniscus Overload

The medical terminology for her problem may seem almost medically Shakespearean: “ACL laxity leading to tibial rotational instability and anterior medial compartment overload.” This basically means the loose ACL caused a rotational instability of the tibia, which led to knee meniscus pain and possibly damage. Have you ever seen dominoes fall? It’s the impact of the first domino on the second domino that causes the third and all subsequent dominoes to fall. When the body is injured, damaged, or sick in some way, there can be a domino effect as well, and this is the case with a loose ACL—it’s the first domino.

Even an ACL that is slightly loose—not something a surgeon would want to replace by any means—can have dramatic, long-term impacts on the anterior medial meniscus (or the front inside meniscus).

You’ll see in the video below that I used an ultrasound probe on the inside front of the knee to image my patient’s meniscus, and then I rotated her good side and I rotated her bad side (the painful side). I saw huge differences just visually, but I was also able to capture those on the ultrasound, and you can see the ultrasound of both sides in comparison on the video.

On the left, when I rotated the tibia, there was a little bit of motion of the tibia on the femur against that side of the meniscus, but it was not dramatic. On the right, when I rotated the tibia, there was a dramatic amount of motion seen on the ultrasound. In fact, I was going faster on the right because it was so loose. In the video you can see how that excessive motion is beating up her meniscus on that side every single time she tries to take a step, as the tibia rotates when you walk. And every single time she makes a pivoting movement, it beats up her meniscus and this corner of the knee even more.

Treating a Loose ACL with Orthobiologics

Loose ACLs can usually be stabilized using a precise injection of orthobiologics, such as platelet rich plasma or bone marrow stem cells. In the case of my patient highlighted in the video, I will harvest and inject the patient’s own bone marrow stem cells, as I have done for many, many years in the treatment of ACLs and to help patients avoid unnecessary ACL surgery.

The upshot? Where the knee pain is located and what’s causing it are often two different things. There’s often a disconnect between what the problem is and where it hurts. If your drawer test comes back normal, but you are clearly still experiencing front inside knee pain, a prescription for pain medication isn’t the answer! Something isn’t right, and it’s important to find the root cause, not only to eliminate your pain but also to repair the issue before more dominoes fall and more damage is done!


    *DISCLAIMER: Like all medical procedures, Regenexx® Procedures have a success and failure rate. Patient reviews and testimonials on this site should not be interpreted as a statement on the effectiveness of our treatments for anyone else.
    Providers listed on the Regenexx website are for informational purposes only and are not a recommendation from Regenexx for a specific provider or a guarantee of the outcome of any treatment you receive.


    can this grabbing sensation be caused by what you have described? What determines if you use stem cells versus PRP? says

    I, also, had your same day stem cell injections two years ago in both knees. I still continue to have issues in one me that sound very similar to the woman you have described. Sometimes it will grab not in the knee but on the medial side below the knee. can this grabbing sensation be caused by what you have described? What determines if you use stem cells versus PRP? Thanks, Sally


    Chris Centeno says

    Sally, yes this can cause the grabbing sensations you describe.


    Vita Landear says

    I have a loose PCL from an auto accident many years ago. It has the positive drawer reflex, and it has gotten worse over the years. I've had arthroscopic surgery on both knees, where meniscus trimmed down significantly. And now have severe degenerative arthritis in both knees. The knee with the loose ligament continuously gets out of alignment, and when moving from sitting to standing, I have to literally snap it back in place (which is accompanied by a loud snapping sound), before coming to a standing position. Would the injection of my own stem cells be an appropriate course of RX for those ligaments? Would that help tighten them and stabilize the knee? My doctor has recommended replacement of both knees. I am trying to avoid that if possible. Any suggestions?


    Regenexx Team says

    Yes. Please see: Unfortunately, the surgeries likely made the situation worse, as removing sections of meniscus leads to further instability and ultimately more arthritis. To see what else is going on and to come up with a treatment plan would require an exam, but if you would like to chat with one of our physicians first to see if you are a good Candidate for a Regenexx Procedure, please fill out the "Am I a Candidate" Form.


    W Ingram says

    Regretfully, stem cell procedure for (r) hip not viable option, too far gone, Nonetheless, (l) hip may benefit. However, only option now is (r) hip replacement. I'm a bit anxious, and not sure what to expect. Any advise Regenexx can share that might ease the process or my mind about the potential upcoming surgery? I'm not too happy about hip surgery.


    Regenexx Team says

    W Ingram,
    When all options have been tried or ruled out, it's really about finding the best fit in 3 areas: the surgeon, the procedure and the prosthesis. This will help with the prosthesis: The procedure or surgery that has gotten a lot of good reviews is the "Anterior Approach" as it doesn't cut through as many structures as the traditional approach. Obviously though, whether a particular approach would be a good fit in your situation is something that would need to be decided by a hip surgeon. As far as the surgeon, if a particular approach or device is decided upon, looking into who has had the most experience with the approach and or device would be very important.


    Prash says

    Hello Dr,

    I have been trying to find the precise diagnosis and treatment for my issue of stiffness and tightness in my hands which is getting severe after couple of traumas with whiplash auto accidents.

    I saw a Dr in Miami Fl who does adipose based stem cells treatment. He boasts treating many athletes.

    He reviewed my MRI and had neck X-ray but did not specially said what is causing the issue or where the problem is.

    Can you advise me how to get the proper diagnosis exam to find the root cause and treatment.? I will really appreciate it.



    Regenexx Team says

    Yes, an exam by someone who has the very specialized skills to diagnose these issues: There is one location in Florida:


    kim says

    Hi Dr. C,
    How about anterior outside knee pain and posterior medial knee pain? I'm told its due to the fairly large full thickness lesion on my lateral trochlear groove. I'm told that biologics would likely be unsuccessful and so resurface is option. My concern is the root cause and also have had 2 surgeries thus far and both have only made situation worse (not to mention the meniscus trim that I have been left with as well). Even if it is too late for stem cell, do you have idea of root cause of these types of injuries?
    Thank you,


    Regenexx Team says

    Yes. Please see: and this one: and this:, and this is the same person:


    Agron Xbudo says

    I had my ACL reconstructed in 2004 and its now become loose overtime. I also had a meniscus surgery on the same knee in 2011, subsequently causing medial pain in my knee as well. I've been following Regenexx for over three years. Would regenexx help? Is regenexx still not cover by health insurance? If not, is there anyway of bringing the cost down and/or is financing available? Thank you


    Chris Centeno says

    Sadly, Meniscus issues following ACL reconstructions are very common. Yes, Regenexx would likely help. Stem cell/regenerative procedures are still not covered by insurance. However, some of our Providers do work with various types of financing plans. Please fill out the Candidate form to speak to one of our Physicians about your case.


    Megan says


    I am very athletic and have had five knee surgeries for medial and lateral meniscus tears. I had the fifth one last year and have since torn my meniscus again and recent mri shows that the arthritis has advanced. I obviously do not want anymore surgeries as this will only further progress the arthritis. I am wondering if I would be a candidate for Regenexx?


    Chris Centeno says

    Most of our knee patients have had prior surgery or surgeries. The important question is what caused the 5 meniscus tears, and our Orthopedic 2.0 exam looks for and we treat the underlying cause as well, as treating a knee leaving it vulnerable to the 6th meniscus tear would be fruitless! To see if you'd be a good Candidate for a Regenexx procedure please fill out the Candidate form which would allow you to upload films and set up a chat with one of our Physicians. (under red Submit button) Alternatively, that process can be done at the time of an exam.


    Rose brink says

    I've had 9 injections with flexogenics my knee still bothers me hard to walk at times especially after waking from sleep or sitting try to get up that really hurts . They said I have a tear in my meniscus and whatever is it worth continuing with them or time to change. This was suppose to work after 5 injections.


    Chris Centeno says

    I would inquire what part of the 5 treatment protocol has the regenerative potential to address your problem. Meniscus tears are rarely the cause of pain or dysfunction except in a rare subset of cases. If you have a tear and haven't had surgery on it you're ahead of the game. Regenexx tackles knee issues like yours by discovering the sources of the problem through an intensive Orthopedics 2.0 exam, and treating the causative issues and the arthritis itself with the appropriate treatments using your own platelets platelets and stem cells.


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    About the Author

    Chris Centeno

    Christopher J. Centeno, M.D. is an international expert and specialist in regenerative medicine and the clinical use of mesenchymal stem cells in orthopedics. He is board certified in physical medicine as well as rehabilitation and in pain management through The American Board of Physical Medicine and Rehabilitation.…

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