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A Maximally Damaged Ankle and Surprising Results

POSTED ON IN Ankle Ankle, Foot and Toe Procedure Outcomes Latest News Regenexx-C BY Chris Centeno

When I first met Don and he showed me his ankle, I think I said or thought, “Wow!” It was twice as big as his other ankle due to the surgical free flaps, and his MRI looked like a bomb had gone off in his talus bone. When we discussed whether stem cells could help, I think he could read my body language, which loudly said, “Uhhhh, maybe?” That’s why this is a fun blog post to write, as Don ultimatley surprised me and then some.

Don’s Ankle

Don fractured his ankle back in the ’80s and had hardware surgically placed to help his damaged bones mend. The ankle then got infected and the hardware was removed, and many surgeries followed, including a free-flap surgery. In this case, that meant taking a muscle from his calf and sewing it over the nonhealing and infected bone to bring more blood supply and healing potential to the area. What he ended up with was an ankle that looked like a tumor had grown around it. That worked reasonably well, until about 3–4 years ago when he began to get arthritis in the main ankle joint. By the time he walked into the clinic for me to check this and other problems, his pain was an 8 out of 10 on medications.ankle anatomy mri

The MRI animated GIF above slices through his ankle sideways. I’ve included one of the slices to the left so you can get oriented. His talus is the oddly shaped bone in the middle, which is where I want you to focus your attention on the image. This bone is one of two (the other being the tibia) that make up the largest ankle joint.

On this type of MRI sequence, the normal bones are black. The bright areas you see in the talus bone above as the slices fly by are areas where the bone is fractured and never fully healed. Any white in this bone is abnormal, but the MRI shows that some of these fractures communicate with the tibiotalar joint, which is not good. In summary, his talus bone is a fragmented mess that never fully healed.

Could we help this ankle?

Don’s Stem Cell Plan

Looking at the severity of what we were dealing with, I steered Don in the direction of cultured stem cells. This means that at our licensed advanced-stem-cell-treatment site in Grand Cayman, we would grow the cells to bigger numbers. This not only made sense for this area, but we had his back and shoulder to treat as well. Using culture expanded cells would make it much more likely that we would have enough cells to treat everything.

I was very concerned that we might have to inject not only into the tibiotalar joint but also into the talus bone. However, that would risk the bone further fragmenting and falling apart; hence, we decided to only treat the joint and hope the cells would make it into the damaged and fragmented bone. This made sense, as there seemed to be actual physical communications between the joint and the pieces of the talus bone.

So how did Don do? He reported to me today that after his treatment in May, some seven months ago, his ankle pain is now down to a 2 out of 10, and he’s off medications. He went skiing this past weekend, and he’s back to activities he couldn’t dream of before. In summary, he did very well.

The upshot? Don’s recovery surprised the heck out of me. However, it goes to show you that even when we place patients in the poor category for a stem cell procedure, sometimes they surprise us. In Don’s case, I’m eager to see a recent MRI and have ordered one. In the meantime, I’m glad that he’s pleasantly surprised and has become our newest Regenexx evangelist!

The Regenexx-C procedure is not approved by the US FDA and is only offered in countries via license where culture-expanded autologous cells are permitted via local regulations.

    *DISCLAIMER: Like all medical procedures, Regenexx® Procedures have a success and failure rate. Patient reviews and testimonials on this site should not be interpreted as a statement on the effectiveness of our treatments for anyone else.
    Providers listed on the Regenexx website are for informational purposes only and are not a recommendation from Regenexx for a specific provider or a guarantee of the outcome of any treatment you receive.


    Susan Dempster says

    I broke my ankle several years ago, hardware was put in but now I have painful arthritis, and my goot/Ankle Surgeon wants to fuse my cuneiform navicular joint.
    I don't want that because it's very painful and assoc with a long recovery!
    I'm checking into Regenex. I am going to a doctor in Oakhurst. NJ to see.if I'm a possibility.
    I've worked on clinical studies as a nurse. But is this procedure FDA approved? I thought it was!
    Is it always best to go to the Cayman Islands? I know they can grow stem cells there but is that what I should do?
    I'm far from rolling in money ... the price would be prohibited, I think! It's my ankle, and I'm in pain!
    I'm now in contact with Dr. AMERSO in Oakhurst, NJ
    I'D LOVE TO BE CONTACTED BY someone else in my predicament !!


    Chris Centeno says

    You'll be in good hands! The initial exam is covered by insurance if you're in network, and Dr. Amoroso will evaluate the situation and tell you honestly whether he thinks we can help, and if so, what he thinks the best course of action would be. That could include the cultured procedure in the Cayman islands if more stem cells than can be obtained in a same day stem cell procedure would be needed. The vast majority of patients are treated with the same day stem cell procedure. Here is more information abot how we treat foot and ankle issues; scroll down to see video of ankle procedure:


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    About the Author

    Chris Centeno

    Christopher J. Centeno, M.D. is an international expert and specialist in regenerative medicine and the clinical use of mesenchymal stem cells in orthopedics. He is board certified in physical medicine as well as rehabilitation and in pain management through The American Board of Physical Medicine and Rehabilitation.…

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