It’s probably not surprising, especially if you read this blog often, but nonsteroidal anti-inflammatory drugs (NSAIDs) are in the news again! This time it’s ibuprofen (e.g., Advil, Motrin, Midol, etc.) and its effect on the kidneys of long-distance runners. Why the focus on an NSAID in this specific group? Because a large majority of this population is known to take NSAIDs before or even during marathons under the belief that they increase their tolerance to pain and minimize swelling during competition. However, a new study suggests they may be giving runners some serious NSAID kidney damage in return.
The new study was conducted under the hypothesis that the risk of kidney damage in long-distance runners using NSAIDs is no greater than it is in runners taking a placebo. For the purpose of this study, subjects were competing in a 50-mile ultramarathon, which is defined as anything over the standard 26.2-mile marathon. The study was a randomized controlled trial (RCT) with a test (ibuprofen) group and a placebo group, totaling 89 subjects in all. It was also double blind, which means neither the subjects nor investigators knew which group the subjects were in during the study. Ibuprofen subjects took ibuprofen at 400 mg (the equivalent to two standard pills) just before the race began and every four hours until the race ended, while the placebo group were given fake pills. Following the race, kidney functions were measured.
The result? Disproving their hypothesis, researchers found that while 44% of all the runners experienced some degree of kidney injury (which is to be expected in runners at this level due to dehydration), there was an 18% jump in kidney injury in runners taking ibuprofen compared to the placebo subjects. In addition, the ibuprofen kidney injury was more severe.
We may sound like an NSAID broken record, but if you’re paying attention, you know that new studies revealing new things about just how dangerous these drugs are just never end. Let’s review some of those side effects:
Additionally, the risks aren’t just in those taking NSAIDs for long periods of time, such as someone with chronic back or knee pain; NSAID use for just one week can increase the risk of a heart attack by a whopping 50%!
Yes. High-quality supplements such as glucosamine and curcumin have been shown to relieve pain and reduce inflammation, even in patients with arthritis. Clinical trials demonstrate that these supplements can be a great substitute even for a prescription NSAID, such as Celebrex. They can be used long term and they don’t carry the dangerous side effects of NSAIDs.
The upshot? Very few of us are probably long-distance runners, and even fewer still run ultramarathons, but the risks of NSAID kidney damage are real whether you’re running 50 miles at a pop or just taking a slow walk around the block. Add to this the long and constantly growing list of other NSAID risks, and there are many, many reasons to stop taking NSAIDs.
*DISCLAIMER: Like all medical procedures, Regenexx® Procedures have a success and failure rate. Patient reviews and testimonials on this site should not be interpreted as a statement on the effectiveness of our treatments for anyone else.
Providers listed on the Regenexx website are for informational purposes only and are not a recommendation from Regenexx for a specific provider or a guarantee of the outcome of any treatment you receive.
About the Author
Christopher J. Centeno, M.D. is an international expert and specialist in regenerative medicine and the clinical use of mesenchymal stem cells in orthopedics. He is board certified in physical medicine as well as rehabilitation and in pain management through The American Board of Physical Medicine and Rehabilitation.…