ACL Tears

70% of ACL tears can be healed without surgery

At Regenexx our goal is to save your ACL, not replace it. Regenexx invented and developed a procedure called the perc-ACLR which stands for percutaneous ACL repair procedure for individuals who may be considering surgery due to a partial or complete non-retracted ACL tear. Skip the ACL surgery and repair your ACL through your body’s natural healing agents.

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Avoid ACL Surgery with Regenexx

Have you been told that invasive surgery is your only option to fix your torn ACL? You have other options when it comes to treating your ACL injury. In fact, your body is built to repair itself. Interventional orthopedics provides a non-surgical alternative that uses your own cells to repair the damage. It uses precise image-guided injections of your own body’s healing agents that can help repair tissue.

An injury to the anterior cruciate ligament (ACL) can cause substantial difficulty with basic mobility and function and is especially common among athletes, including professional ones. From NBA point guard Derrick Rose to U.S. soccer player Alex Morgan, ACL injuries and ACL surgeries occur in just about every sport. Strains or sprains to the ACL typically heal with rest, but at the point of ACL tear, the main treatment option is ACL surgery involving applying a tissue graft taken from elsewhere in the body or a cadaver. This graft attaches at a steeper angle than the original tendon which causes more compression on the cartilage in the knee and greatly increased chance of osteoarthritis while the position sense and strength in the repaired knee are never the same. In addition, as is typical with orthopedic surgeries, patients who get this surgery are significantly more likely to experience additional knee injuries. The Regenexx perc-ACLR procedure is an injection-based procedure that can replace 70% of ACL-repair surgeries. During this outpatient procedure, our expert physicians use precise image guidance to inject custom concentrations of your body's natural healing agents into the precise areas of damage to tighten and stabilize your knee joint for better function and mobility. Call our patient care coordinators today to get started on your path to ACL recovery.

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Knee ACL
Jason Markle, M.D.
If you don't put a precise injection into the ACL, it will never get there.

Jason Markle, M.D., Regenexx Physician

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John Schultz, M.D.
You have to inject the origin and the insertion of the anterior medial and posterolateral fibers. It's only then you get the best possible outcome.

John Schultz, M.D., Regenexx Physician

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Ryan Tannehill
When I found Regenexx, I found out they had the most thorough and precise procedure out there. I want to get the message out.

Ryan Tannehill, American Football Quarterback

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Chris Centeno, M.D.
"I've been doing orthopedic stem cell work longer than any other physician in the United States. I invented much of this field."

Chris Centeno, M.D., Regenexx Founder

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How Does the Perc-ACLR Procedure Work?

The procedure occurs over the course of a week, although each patient and their ACL injury varies. On the first day the pre-injection occurs. This is a special hypertonic dextrose solution that creates a mild inflammatory environment that is conducive to healing. This visit usually lasts between 30 to 40 minutes.

The second day is the stem-cell procedure. After a local anesthetic is applied, the physician will draw bone marrow from the back of your iliac crest using precise image guidance. Drawing from both hip bones usually takes 30 to 60 minutes and is significantly less invasive than a bone marrow biopsy.

Once the marrow is drawn and processed by a Regenexx lab technician, you will have time to relax before the re-injection of the harvested stem cells into your ACL. The re-injection happens between three to eight hours after drawing the bone marrow. Again, local anesthesia is used before the re-injection takes place, using real-time imaging guidance which in this case is fluoroscopy. Patients may be asked to stay in the clinic 30 to 60 minutes after re-injection.

The last day includes a blood draw and post-injection of Regenexx’s proprietary platelet-rich plasma concentrations. This procedure takes between 20 to 30 minutes.


What does a torn ACL recovery time look like after the outpatient procedure? During the first 24 hours, you should limit your joint activity/range of motion and wear the recommended boot or knee brace.   

Your joint will be sore for one to three days, but as most patients note, they see improvement to their ACL within the first month. Pain will become less severe and frequent and within five to seven days, patients can resume light activities and begin physical therapy.

Six to eight weeks later, patients can begin to resume more vigorous exercises and regular routines and will continue to see ACL improvement and healing month after month. We should see maximum ligament repair and tightening in younger patients at 3-6 months and in older patients up to 9-months.

However, results vary by patient and depend on the condition of the area treated, age, and general health of the patient.

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The Regenexx Difference

At Regenexx, we offer a unique approach to treating orthopedic injuries non-surgically based on more than a decade of research and experience.

We have spent years conducting research and publishing studies to establish and provide the best clinically proven outcomes to treat your ACL.

13 Years Experience

Regenexx invented the perc-ACLR procedure to avoid ACL reconstruction surgery and continues to advance interventional orthopedics for the ACL.

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The Knee-Owner's Manual

This free e-book by Chris Centeno, M.D. examines the knee and its role within the human musculoskeletal system and the body as a whole.

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Published Studies

Regenexx published a clinical study in 2018 and one in 2015 and has an ongoing RCT (randomized control trial) to continue to research the procedure outcomes.

ACL Clinical Studies

Patient Focused

Regenexx provides objective analysis of an individual’s ACL condition and rates their expected candidacy of success before committing to a procedure. Being informed allows you to make smart choices.

ACL Candidacy

Regenexx Results

Since 2005 we have conducted research, accumulated patient results data and obtained direct feedback from our patients. With one purpose in mind. To help you make an informed, confident decision to treat your condition.

Patient Results

Regenexx has an ongoing RCT (randomized control trial) to investigate the efficacy of our procedure.

RCT Results

 Before & After MRI Images

We have accumulated patient imaging before and after a Regenexx procedure to document anatomy change.

MRI Results

ACL Videos

Watch videos about the Regenexx Perc-ACLR procedure, patient results, and ways Regenexx can repair ACL tears.

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Are You A Candidate for the
Regenexx perc-ACLR Procedure?

Speak with a Regenexx patient liaison to learn more
about what we can do for your ACL tear.

  • We listen to your specific situation and concerns
  • We answer questions related to your ACL and Regenexx
  • We explain the patient process for considering a perc ACLR procedure
  • We can schedule a time to meet with a Regenexx physician near you

Get Started      855-330-5818

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Why Regenexx?

Did you know that Regenexx was the first to use stem cells to treat orthopedic injuries? In fact, Regenexx has developed many of the processing and treatment techniques in use today and has published roughly half of all research worldwide on the use of mesenchymal stem cells for treatment of orthopedic injuries.

Our approach is rooted in our research and is constantly being refined and developed as we continue to lead the way in finding better methods for harnessing your body’s own healing agents to repair damaged tissue. Our proprietary, evidence-based protocols lead to unparalleled results.