Disc Replacement Side Effects: New Research Is Concerning - Regenexx®

Disc Replacement Side Effects: New Research Is Concerning

The whole idea behind disc replacement is that it should have fewer side effects than fusing the spine. The artificial disc allows motion, which is, in theory, similar to a normal biologic disc. However, what if an artificial disc ended up distorting normal motion so badly that it still caused the disc above and below to fail, just like a fusion? A new study suggests that abnormal motion in these devices may be responsible for a whole new class of disc replacement side effects.

The Concept Behind an Artificial Disc

The concept behind disc replacement is to try to eliminate pain and retain movement in the spine by removing an injured disc and replacing it with an artificial (metal or plastic) one, about the size of a small hockey puck. This is in contrast to a fusion where the disc would be removed and the vertebrae fused together to stop movement in that part of the spine. While on the surface it sounds like a better option than a fusion, this is also a very big surgery that can lead to many problems, such as wear-and-tear ions (from metal- or plastic-device breakdown) in the blood, revision surgeries, ongoing pain, and now as the new study shows even adjacent segment disease (typically associated with fusions) due to abnormal motion in the spine.

Before we look at our feature study, let’s review some prior studies we’ve covered concerning disc replacement side effects.

Other Studies Looking at Disc Replacement Side Effects

We’ve known about metal ions in joint-replacement devices, such as knees and hips, for a long time, but a recent study also found significant metal ion concentrations in the blood of patients who’d had cervical disc replacements.

Another study found tissue reactions to wear particles that were just as severe following disc replacement as they were following hip or knee replacements. The most concerning issue was that inflammatory cells were found alongside the wear particles, and unlike in the hip or knee, the spinal nerves are very close here, so inflammation in this area will cause other symptoms.

While this one isn’t a study, it shows a disturbing issue: even young people, as young as teens, are being offered these surgeries despite the serious fusion and disc replacement side effects The young patient featured in the linked post was on the path to disc replacement surgery when her insurance, thankfully, rejected not only the disc replacement but also the aggressive fusion surgery. She was able to find relief through precise injections of her own growth factors.

What Is Adjacent Segment Disease?

To understand adjacent segment disease (ASD), you need to understand the structure of the spine. There are 24 movable vertebrae or back bones. These stack one of top of the other, and stretch from the neck all the way down to the lower back. Between each vertebra is a disc that provides a cushion, and the vertebrae meet in the back at facet joints at each disc level. All of this functions to protect the spinal cord, that big bundle of nerves that runs through our spinal column.

In a fusion, the hardware is installed along two or more vertebrae to permanently “lock,” or immobilize the fused vertebrae. ASD occurs when the fused section overloads the vertebrae above and below it, causing a breakdown in those neighboring unfused levels as well. In ASD bone spurs and arthritis develop, causing a significant amount of pain.

While we’ve know fusion leads to ASD, we’re now finding out that ASD may also be a disc replacement side effect. Let’s look at the new research.

The New Research

The purpose of the new study was to look at the configuration of the vertebral joints and disc in patients who’d had a total disc arthroplasty (TDA), or disc replacement. Researchers concluded, “Under axial rotation of the cervical spine, additional lateral and/or ventral/dorsal displacements are produced by TDA. Consequently, adjacent level disease (ALD) may be mechanically stimulated.” So while adjacent segment disease can be caused by the lack of movement created by fusion surgery locking the spine in place, this study shows it can also be caused by the abnormal motion in the spine that is created by a disc replacement.

The upshot? There is no free lunch in spine surgery. Meaning that all of it is causing damage at some level in an attempt to restore something. In most cases we see, the risks often outweigh the benefits, and in some cases the risk of damage due to surgery is reasonable. In the case of disc replacement side effects, abnormal motion created by these devices may get rid of the main argument for using them—that they don’t cause adjacent segment disease. In fact, the opposite may be true!


*DISCLAIMER: Like all medical procedures, Regenexx® Procedures have a success and failure rate. Patient reviews and testimonials on this site should not be interpreted as a statement on the effectiveness of our treatments for anyone else.
Read 17 Comments
    1. Chris,
      Both systems hydrate the disc and take pressure off the structure. Please see:https://www.regenexx.com/sitting-and-sciatica-pain/ A recent study looked at what type of exercise was helpful, and what type to avoid in DDD recently, and found one type of exercise had some regenerative potential:https://www.regenexx.com/ddd-and-exercise/ Exercise can be a good tool in working to manage pain in Degenerative Disc Disease by increasing stability. If significant improvement is not gained because the damage is too great, using your own platelets and stem cells have shown good results in addressing the physiopathology involved in DDD: bulging discs which irritate nerves, instability which leads to bone spurs, and painful facet joints.

  1. Please don’t stop these blogs , as l am being enlightened to understand why 80% of doctors diagnosis are wrong . Nothing finer than a honest man telling the truth ; you are compared to confusia of ancient china .

  2. I appreciate this blog. I had Arthroplasty December of 2015 and I’ve had pain in my shoulders, arms, hips and legs. It is frustrating because my lab work only shows Vitamin D & B deficiencies and no inflammatory or connective tissue issues. It makes me feel like a hypochondriac because nothing makes any sense as to why I’m having this pain. I have osteophytes and metal artifacts shown on MRI, as well as a T12 lesion (probably hemangioma) on MRI as well. Any advice? They put me on 1200mg Gabapentin daily.

    1. Carah,
      Was this a disc replacement or another joint? We’d need to see you to figure out what’s going on. You can submit the Candidate (to the right of the blog) form if you have a recent MRI to set up a candidacy evaluation by phone. Or you can set up an exam at any of these Regenexx locations with Spine to the right of the name: https://www.regenexx.com/find-a-physician/

    2. I had a disc replacement, Jan 2015, at c5/c6. While the radiating pain in the right arm was mostly alleviated, I now have a whole new host of issues! I have pain in my shoulders, arms, collarbone and neck. I suffer chronic headache and I find most daily chores involving lifting, weight baring and raising the arms above shoulder height especially triggering. Glad to hear of others who’ve had further symptoms and it’s not just all in my head!

  3. I have Charite disc replacement in 2006. After surgery I had lots of pain relief, including epidurals. Eventually after pain relief via a procedure through my back I was actually free from pain in 2010. Over the last year the pain has returned and has gradually increased to me not being able to just do what I would call, normal things, i.e. getting out of bed in the morning, emptying the dishwasher, without increased pain. If I wake up on my back I’m in agony trying to turn round, the pain actually comes from the back through to my pelvic area, and today has been my worse. I’ve spent the last 5 hours with constant pain, plus shooting nerve pain on the right side, just above my right hip. I’ve been told I cannot go back to the consultant till I try physio. I was given 1 session, then discharged 5 minutes into my 2nd, they said physio was the correct way forward for me. So I’m now due to see a consultant in 2 months. Has anybody else had these pains at all – if, so what happened?

    Many thanks


    1. Anita,

      It sounds like you might be in the UK? We’ve known fusion causes adjacent segment disease for a long time, and although disc replacement was conceived to prevent that, it hasn’t. With lumbar fusion, the hip is often affected. Please see: https://www.regenexx.com/yet-another-rason-low-back-fusion-mostly-dumb-idea/ and https://www.regenexx.com/disc-replacement-side-effects/ and https://www.regenexx.com/neck-epidural-failed/ If you are in the UK and would like to see if we can help, we have a Regenexx location in Brussels. Please see: http://oreme.eu/https://www.regenexx.com/find-a-physician/

  4. I had a Bryan disc replacement C5-6 about two years ago in Seattle. I ha d a great MD who did my surgery. BEFORE surgery he indicated my disk had completely failed and a second C6-7 was also becoming a problem. I’ve been very happy with the outcome of the surgery, but now some two years later I’m getting similar symptoms as I had before surgery. Right hand numbness during sleep, general Right sided neck pain and at times Right shoulder pain.

    Anyway, this comes as no surprise to me as I was told about the second weakened disc and viewed it on both x-ray and CT. I’m not at all concerned about a potential second surgery, but would like to get some input here. As I understand it the FDA allows for a second “stacked” disc. One final question, should I be concerned about chiropractic treatments? I’ve not had any since surgery but am considering it now to stave off surgery.


    1. Dave,
      The symptoms mentioned are likely originating from that area. Please see: https://www.regenexx.com/a-colorado-regenexx-patient-review-pain-free/ As it discusses in the blog, while disc replacement was originally developed to avoid the Adjacent Segment Disease caused by fusion by allowing motion, unfortunately, ASD has been associated with Disc replacement as well. Please see: https://www.regenexx.com/pain-after-back-fusion-adjacent-segment-disease/ We treat ASD regularly, as well as the issues that disc replacement seeks to fix, nonsurgically, but we’d need more information through the Candidacy process to advise. If you’d like to do that, please submit the Candidate form. https://www.regenexx.com/the-regenexx-procedures/back-surgery-alternative/ An MRI would be needed.

  5. I would be interested to see your thoughts on the newer 3rd generation discs such as the spinal kinetics M6 and LP ESP available in europe. admittedly still artificial, these have been designed to mimic the motion and shock absorption of the disc (extensive lab testing and now >9 years use, 50K implants worldwide for M6). It appears heads and shoulders above the first and second generation discs to which these studies you reference refer. some patients may not respond to biologics so other options besides fusion and older disc technology are now available. Its moving in the right direction. Obviously surgery is still a risk but sometimes it is needed and can be a terrific option in the right surgical hands for the right indication. and if done well it can essentially replace the natural tissue which just doesn’t have the capacity any more.

    1. Ken, medical care should always progress from less invasive to more. Right now, advanced spinal biologics fill that doughnut hole between traditional PT and block shop procedures and invasive surgery. We can prevent most patients from needing a disc replacement. I suspect that as spinal biologics mature and get better coverage, the number of disc replacement procedures will drop. However, better disc prostheses are always welcome for patients that can’t be treated in any other way.

      1. That is fair and agree wholeheartedly. I myself have tried bioligics and am trying to remodel and help my spine naturally. It isn’t easy but believe it can be done to get improvement.

        Surgery still should remain a last option but at least things are getting better from the days of old.

        Thank you

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