Knee Meniscus Treatment Case Study

Dr. Centeno’s Analysis:

This is a tale of several patients with a common problem and result. One of the most exciting things about the Regenexx knee procedure is its ability to increase the size of the meniscus. To understand this, it’s helpful to understand something about the knee, so part of these case reports are focused on basic knee anatomy.

The knee has a shock absorber structure called the meniscus. This “knee cartilage” is a cushion between the bones of the knee. When it gets torn or starts to wear out, the bones of the knee get less protection and the cartilage covering these bones can also wear out. This can create a “bone on bone” situation. This whole problem could be improved if it was possible to increase the size of the meniscus or “shock absorber” so it could provide better cushion.


We tested these theories in our own Phase III clinical trial. In this trial, we tested various types of joint treatment added to the patient’s own stem cells. The majority of these patients reported significant relief of their symptoms. We then used a computerized analysis software to determine the size of the meniscus before and after the procedure. The most interesting part was that, in many of these patients, the size of the meniscus increased. From there, we were able to decide which injection techniques would allow us to obtain consistent results for patients. Patient was treated with Regenexx-C Procedure.

Below is a graphical analysis of this increase in meniscus size, versus the patient’s age in decades (four means they were 40-50 years old), the length of time their cells were grown in culture (less is generally better). In addition to increased meniscus size on high resolution MRI, these same patients also had significant relief. Note that we were able to increase meniscus size by about one-third from a single injection procedure.

Change in Meniscus and Cartilage Volume as Measured on 3.0 T MRI