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Regenexx® Stem Cell & Platelet Procedures for Knee Arthritis, Meniscus Tears, Tendon & Ligament Tears, Overuse Injuries and Other Conditions.

Regenexx® Stem Cell & Platelet Rich Plasma Procedures are the world’s most advanced regenerative injection treatments for treating knee pain due to arthritis, meniscus tears, traumatic ligament injuries, overuse conditions and other degenerative conditions.

If you have encountered an injury to the knee meniscus, cartilage, ACL or MCL ligaments, or have chronic knee pain due to a past injury or arthritis, you may be a good candidate for knee stem cell therapy or platelet rich plasma procedures. Traditional options for patients suffering from these issues include arthroscopic knee surgery to repair ligament tears, or total knee joint replacement. With both surgeries, months of rehab are required to regain strength and mobility, and the patient must be aware of and prepared for associated risks.

Patient Outcome Data & Commonly Treated Knee Conditions

Regenexx is the only stem cell treatment network to publish this type of analysis of patient stem cell procedure outcome data. The analysis is made possible thanks to the massive numbers that are compiled throughout the years in the Regenexx patient registry, which tracks patient outcomes at regular intervals following all of the stem cell procedures we offer.

Note: This patient outcome data is not part of a controlled trial. Every patient becomes part of a registry to track outcomes and any complications. This data is a compilation of patient input to the Regenexx Patient Registry at regular intervals following their Regenexx Procedure. In addition, none of this data may be reproduced in any way or displayed elsewhere without prior written permission from Regenerative Sciences.

NEW! View the latest patient outcome metrics in our Patient Outcome Reporting Application.

  • Knee Patient Outcome Data

    This Regenexx bone marrow derived stem cell treatment outcome data analysis is part of the Regenexx data download of patients who were tracked in the Regenexx advanced patient registry.

    View Knee Patient Outcome Data
  • Knee Meniscus Procedure Outcome Data

    This Regenexx bone marrow derived stem cell treatment outcome data analysis is part of the Regenexx data download of patients who were tracked in the Regenexx advanced patient registry following treatment for Meniscus Tears.

    View Knee Meniscus Procedure Outcome Data
  • Knee Function Improvement Data

    This data utilizes LEFS (Lower Extremity Functional Scale) data from our knee arthritis patients treated with stem cell injections. Functional questionnaires ask the patients questions such as how well they can walk, run, climb stairs, etc. The improvements following the Regenexx Stem Cell Procedure are highly statistically significant.

    View Knee Function Improvement Data
  • Stem Cell Procedure Safety

    Regenexx has published more data on stem cell safety in peer reviewed medical research for orthopedic applications than any other group world-wide. This is a report of 1,591 patients and 1,949 procedures treated with the Regenexx Stem Cell Procedure. Based on our analysis of this treatment registry data, the Regenexx Stem Cell Procedure is about as safe as any typical injection procedure, which is consistent with what we see every day in the clinic.

    View Stem Cell Procedure Safety

Commonly Treated Knee Conditions

This is not a complete list, so please contact us or complete the Regenexx Candidate Form if you have questions about whether you or your condition can be treated with these non-surgical procedures.

  • Arthritis
  • Meniscus Tears
  • ACL, MCL, PCL or LCL sprain or tear
  • Knee Instability
  • Patellofemoral Syndrome/Chondomalacia
  • Pes anersine bursitis
  • Baker’s cyst
  • Patellar tendonitis
  • Biceps Femoris Insertional Tendinopathy
  • Hamstrings Tendinopathy

How it Works

Stem Cell Treatments

Same Day Stem Cell Protocol (USA & International) & Cultured Stem Cell Procedure (Cayman Islands Only)

Adult stem cells are cells from your own body that can renew themselves and turn into other cells (differentiate). They live inside all of us in various tissues, poised to leap into action to repair damage as it occurs. As we age or have big injuries, we may not be able to recruit enough of these cells to the site to fully repair the area. Regenexx Stem Cell Procedures help overcome this problem by extracting stem cells from an area of high volume, then concentrating the cells and reinjecting them into the damaged area to help the body heal naturally.

Our Patented Stem Cell Procedures can be used for a wide range of conditions and are the tool of choice for injuries, arthritis and other conditions that may be more significant than what may be treated with our Platelet Rich Plasma or Platelet Lysate Procedures.

Blood Platelet Treatments

Super Concentrated Platelet Rich Plasma & Advanced Platelet Lysate Procedures (USA & International)

Platelet Rich Plasma (PRP) and Platelet Lysate Injection Treatments contain healing growth components from your own blood that increase your body’s natural ability to repair itself. The use of PRP to repair joint, tendon, ligament, and muscle injuries is becoming well known, thanks to exposure from professional athletes. Platelet injection treatments are effective because they have a stimulating effect on the stem cells within the targeted area, making those stem cells work harder to heal damaged tissues.

Our Advanced Platelet Procedures are more pure and concentrated than those created by the automated machines used at most regenerative medicine clinics. Platelet procedures are commonly used for soft tissue injuries, mild arthritis and spine conditions.

Join Dr. Chris Centeno for a Regenexx Knee Webinar!

Dr. Chris Centeno, founder of the Regenexx Procedures, presents this webinar explaining why Regenexx Procedures are the top option that you need to consider if you’re experiencing knee pain from arthritis, sports injuries, previous surgeries, meniscus tears, ACL tears and more. Dr. Centeno explains why each condition is unique and shares real-world examples, imaging and stories in this knee-specific webinar. Register below for this on-demand webinar, available every hour on the hour.

Register for this Webinar

Learn About the #1 Stem Cell & Platelet Procedures for Treating Knee Arthritis and Common Knee Injuries - Regenexx

Next Webinar Begins in Minutes

The Most Advanced Orthopedic Stem Cell Protocol in the World

  • 100% Focused on Orthopedic Conditions & Producing the Best Possible Outcomes
  • Up to 20 Times More Stem Cells Than Standard Stem Cell Procedures
  • The Most Researched Stem Cell Protocol for Orthopedic Conditions
  • Image-Guided Cell Injections & Harvesting for Absolute Precision
  • Bone Marrow Derived Stem Cells Outperform Fat Derived Cells
  • A Complete Stem Cell Protocol - Not a Single Procedure
  • Annually Published Patient Outcomes and Safety Data

Explore The Regenexx Difference

Your Alternative to Knee Surgery

Surgical options for those dealing with painful knee issues range from arthroscopic knee surgery to total knee joint replacement. Recent research has shown that some of the most popular arthroscopic surgeries have no benefit at all (including meniscus surgery). Knee replacement is extremely traumatic and carries new-found risks of toxic wear particles entering the blood stream. Surgical risks aside, all surgeries minimally require months of painful rehab to regain strength and mobility. Most surgeries also accelerate the cascade of degeneration that leads to osteoarthritis.

Surgery is sometimes the obvious solution for severe cases and we acknowledge that stem cells cannot treat everything. However, we have seen exciting results on difficult cases, such as complete muscle and ligament tears, and we have helped thousands of patients with severe arthritis avoid knee replacement and continue to do the things they love with little or no pain. Most Regenexx patients experience little or no downtime from their procedure and are encouraged to return to activity as they begin to feel better.

Percutaneous Knee Arthroplasty with either HD-BMC or Culture Expanded Mesenchymal Stem Cells


In this non-surgical procedure, a highly skilled physician uses precise fluoroscopy and/or ultrasound guidance to inject either high dose (HD) same day or culture expanded stem cells into specific portions of the knee joint that have damage. Candidacy-Knee osteoarthritis, with our procedure, review of registry data demonstrates that patients with mild, moderate, and severe arthritis have the same likelihood of success. Rehabilitation- An unloader or a patellar stabilizing brace may be used to allow the area to be off loaded. Most knees will be rehabilitated with a return to usual activity as tolerated over 6-12 weeks (i.e. any activity as long as pain from the tear doesn’t exceed 2/10).


Percutaneous Anterior Cruciate Ligament Repair with either HD-PRP or HD-BMC


In this non-surgical procedure, a highly skilled physician uses precise fluoroscopy guidance to inject either high dose platelet rich plasma or stem cells into very specific areas of the damaged anterior cruciate ligament (ACL). For this procedure to be maximally successful, the physician must inject the cells into both origin and insertion sites of both bundles of the ACL ligament. Candidacy-All partial and most complete or full thickness ACL tears (retracted up to 1 cm) with a posterior tibial offset of less than 5-6 mm Rehabilitation-An ACL brace is often used. The rehab time is generally about half as much as a surgical reconstruction. The goal is 6 weeks of brace use with in-line activity and then moving to more aggressive cutting when the ACL laxity is no longer present on exam (i.e. for many patients this will be at 6 weeks, for some at 12 weeks).

Percutaneous Posterior Cruciate Ligament Repair with either HD-PRP or HD-BMC


In this non-surgical procedure, a highly skilled physician uses precise fluoroscopy guidance to inject either high dose platelet rich plasma or stem cells into the torn or damaged areas of the posterior cruciate ligament (PCL). For this procedure to be maximally successful, the physician must inject the cells into both origin and insertion sites of the PCL ligament.


Candidacy: All partial and most complete or full thickness PCL tears.


Rehabilitation: A hyper-extension knee brace is often used. The rehab time is generally about half as much as a surgical reconstruction. The goal is 6 weeks of brace use with in-line activity and then and then moving to more aggressive cutting when the ACL laxity is no longer present on exam (i.e. for many patients this will be at 6 weeks, for some at 12 weeks).

Percutaneous Medial Collateral Ligament Repair with either HD-PRP or HD-BMC


In this non-surgical procedure, a highly skilled physician uses precise ultrasound guidance to inject either high dose platelet rich plasma or stem cells into the torn or damaged areas of the medical collateral ligament (MCL). The integrity of the ligament is observed as the ligament is injected, allowing a much higher detail study of the ligament structure than would be possible on MRI. The areas with the most damage are fenestrated using a fine needle technique (multiple small holes are created in the damaged area to stimulate healing and cell engraftment, not unlike aerating a lawn in spring).


Candidacy: All partial and most complete or full thickness MCL tears (non-retracted)


Rehabilitation: A lateral unloader brace may be used to allow the MCL to be placed in a slightly lax position, but most tears will be rehabilitated with activity as tolerated (i.e. any activity as long as pain from the tear doesn’t exceed 2/10).

Percutaneous Lateral Collateral and Anterior Lateral Ligament Repair with either HD-PRP or HD-BMC


In this non-surgical procedure, a highly skilled physician uses precise ultrasound guidance to inject either high dose platelet rich plasma or stem cells into the torn or damaged areas of the lateral collateral and anterior lateral ligament (LCL and ALL). The integrity of the ligament is observed as the ligament is injected, allowing a much higher detail study of the ligament structure than would be possible on MRI. The areas with the most damage are fenestrated using a fine needle technique (multiple small holes are created in the damaged area to stimulate healing and cell engraftment, not unlike aerating a lawn in spring).


Candidacy: All partial and most complete or full thickness LCL and/or ALL tears (non-retracted)


Rehabilitation: A medial unloader brace may be used to allow the LCL or ALL to be placed in a slightly lax position, but most tears will be rehabilitated with activity as tolerated (i.e. any activity as long as pain from the tear doesn’t exceed 2/10).

Percutaneous Patellar Tendinoplasty with either HD-PRP or HD-BMC


In this non-surgical procedure, a highly skilled physician uses precise ultrasound guidance to inject either high dose platelet rich plasma or stem cells into the torn or damaged areas of the patellar tendon. The integrity of the ligament is observed as the ligament is injected, allowing a much higher detail study of the ligament structure than would be possible on MRI. The areas with the most damage are fenestrated using a fine needle technique (multiple small holes are created in the damaged area to stimulate healing and cell engraftment, not unlike aerating a lawn in spring).


Candidacy: All partial and some complete or full thickness patellar tendon tears (without retraction)


Rehabilitation: An knee brace with extension assist and flexion lock may be used. The rehab time is generally about half as much as a surgical reconstruction. The goal is 6 weeks of brace use without knee bending or kicking activity and then OK to move to more to simple knee extension activities depending on healing (i.e. for many patients this will be at 6 weeks, for some at 12 weeks).

Percutaneous Quadriceps Tendinoplasty with either HD-PRP or HD-BMC


In this non-surgical procedure, a highly skilled physician uses precise ultrasound guidance to inject either high dose platelet rich plasma or stem cells into the torn or damaged areas of the quadriceps tendon. The integrity of the ligament is observed as the ligament is injected, allowing a much higher detail study of the ligament structure than would be possible on MRI. The areas with the most damage are fenestrated using a fine needle technique (multiple small holes are created in the damaged area to stimulate healing and cell engraftment, not unlike aerating a lawn in spring).


Candidacy: All partial and most complete or full thickness patellar tendon tears (without retraction)


Rehabilitation: An knee brace with extension assist and flexion lock may be used. The rehab time is generally about half as much as a surgical reconstruction. The goal is 6 weeks of brace use without knee bending or kicking activity and then OK to move to more to simple knee extension activities depending on healing (i.e. for many patients this will be at 6 weeks, for some at 12 weeks).

Percutaneous Popliteus Tendinoplasty with either HD-PRP or HD-BMC


In this non-surgical procedure, a highly skilled physician uses precise ultrasound guidance to inject either high dose platelet rich plasma or stem cells into the torn or damaged areas of the popliteus tendon. The integrity of the ligament is observed as the ligament is injected, allowing a much higher detail study of the ligament structure than would be possible on MRI. The areas with the most damage are fenestrated using a fine needle technique (multiple small holes are created in the damaged area to stimulate healing and cell engraftment, not unlike aerating a lawn in spring).


Candidacy: All partial and most complete or full thickness patellar tendon tears (without retraction)


Rehabilitation: No bracing is used. Most knees will be rehabilitated with activity as tolerated (i.e. any activity as long as pain from the tear doesn’t exceed 2/10).

Percutaneous Distal Biceps Tendinoplasty with either HD-PRP or HD-BMC


In this non-surgical procedure, a highly skilled physician uses precise ultrasound guidance to inject either high dose platelet rich plasma or stem cells into the torn or damaged areas of the distal biceps tendon. The integrity of the ligament is observed as the ligament is injected, allowing a much higher detail study of the ligament structure than would be possible on MRI. The areas with the most damage are fenestrated using a fine needle technique (multiple small holes are created in the damaged area to stimulate healing and cell engraftment, not unlike aerating a lawn in spring).


Candidacy: All partial and most complete or full thickness patellar tendon tears (without retraction)


Rehabilitation: No bracing is used. Most knees will be rehabilitated with activity as tolerated (i.e. any activity as long as pain from the tear doesn’t exceed 2/10).

Percutaneous Distal Iliotibial Band Tendinoplasty with either HD-PRP or HD-BMC


In this non-surgical procedure, a highly skilled physician uses precise ultrasound guidance to inject either high dose platelet rich plasma or stem cells into the torn or damaged areas of the distal ITB tendon. The integrity of the ligament is observed as the ligament is injected, allowing a much higher detail study of the ligament structure than would be possible on MRI. The areas with the most damage are fenestrated using a fine needle technique (multiple small holes are created in the damaged area to stimulate healing and cell engraftment, not unlike aerating a lawn in spring).


Candidacy: All partial and most complete or full thickness patellar tendon tears (without retraction)


Rehabilitation: No bracing is used. Most knees will be rehabilitated with activity as tolerated (i.e. any activity as long as pain from the tear doesn’t exceed 2/10).

Percutaneous Pes Anersine Tendinoplasty with either HD-PRP or HD-BMC


In this non-surgical procedure, a highly skilled physician uses precise ultrasound guidance to inject either high dose platelet rich plasma or stem cells into the torn or damaged areas of the pes anserine tendons (Semitendinosis, Gracilus, Sartorius). The integrity of the ligament is observed as the ligament is injected, allowing a much higher detail study of the ligament structure than would be possible on MRI. The areas with the most damage are fenestrated using a fine needle technique (multiple small holes are created in the damaged area to stimulate healing and cell engraftment, not unlike aerating a lawn in spring).


Candidacy: All partial and most complete or full thickness patellar tendon tears (without retraction)


Rehabilitation: No bracing is used. Most knees will be rehabilitated with activity as tolerated (i.e. any activity as long as pain from the tear doesn’t exceed 2/10).

The Knee Owner’s Manual — How to Avoid Game Changing, Invasive Knee Surgeries and Stay Active as You Age

This e-book by Dr. Chris Centeno examines the knee and its role within the human musculoskeletal system and the body as a whole. Using the Regenexx SANS approach, The Knee Owner’s Manual provides a series of tests and clearly defined exercises that you can do on your own to measure and monitor your own knee health. It will allow you to investigate where your own body might be struggling to maintain proper stability, articulation, symmetry, and neuromuscular function and will help you make the connections between these deficiencies in other parts of the body and the knee. The Knee Owner’s Manual also explores how Regenexx is pioneering the new field of interventional orthopedics, where the use of regenerative biologic treatments, such as adult stem cell therapy and platelet rich plasma, are being used to help repair and strengthen damaged tissues not only in the knee but in the entire musculoskeletal system. This is contrasted with invasive knee surgeries, which often remove important tissues or replace the entire knee itself when it becomes damaged. With hyperlinks to more detailed information, related studies, and commentary, this book condenses a vast amount of data, images, and resources into an enjoyable and informative read. This is the first edition of The Knee Owner’s Manual, a companion book to Orthopedics 2.0.


The Knee Owner’s Manual Download

Regenexx Procedures at a Glance

Typical Condition Severity

$$$ Cultured Stem Cell Procedure (Cayman Islands Only)*
$$ Stem Cell Treatment Protocol (USA & Worldwide)
$ Platelet Rich Plasma & Platelet Lysate
Strains, muscle, ligament & tendon tears, overuse injuries, tendonitis & tendonosis, minor arthritis, joint maintenance, bulging or herniated discs, degenerative discs.
More severe muscle, ligament & tendon tears (including complete tears), joint arthritis, degenerative joint conditions, torn spinal discs, degenerative discs, avascular necrosis, bone conditions & non-union fractures.
Similar to USA Stem Cell Treatment, but stem cells are cultured to greater numbers.* Recommended for severe injuries, arthritis, advanced degenerative conditions, more severe spine conditions.
*Advanced culture expanded stem cell procedure-not approved by the USFDA and available only through licensed sites where culturing cells are the practice of medicine.

More Detailed Information for Common Knee Conditions

Osteoarthritis

Knee replacement surgery comes with many serious risks and complications, but is often considered to be a straightforward and accepted approach to treatment for those suffering from significant arthritis or injury in this joint. Before you consider knee replacement, learn what Regenexx can do for you and download our free report.

Meniscus Tears

Around our Regenexx® Network, meniscus tears are one of the most common injuries we treat. The last option anyone should consider for treating a meniscus injury is the surgical removal of all or some of this important structure. Click below to learn why Regenexx is likely a better choice than meniscus surgery.

ACL Tears

Knee ACL tears are a very common injury. The rush to surgery has long been due to the traditional thinking that an ACL will not heal. Our experience treating ACL tears with the Regenexx patented stem cell treatment has shown that it may be a better option for those who have experienced a partial or complete non-retracted ACL tear.

Free Report: 10 Rarely Discussed Facts About Joint Replacement Surgery

Knee and hip replacement surgeries come with many risks and complications. Several years ago we queried the National Sampling System for Medicare and found that in the year 2008 alone, there were 17,500 serious complications related to knee replacement surgery resulting in 5,000 patient deaths.

If joint replacement is an option for you, please take the time to read this report. These 10 facts come from the Regenexx website. Our goal is to provide information that will help you make the right choice for you.

Recent Regenexx Knee Articles & Patient Stories

Regenexx SD Knee Update: Joe Young Going Strong!

We track patients in a Registry which tracks pain and function scores and outcome over time, and guides research and treatment decisions…but we love hearing directly from our pateints! This Regenexx SD knee update made us smile! Readers of this blog will...
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Land like a Ballerina to Avoid Female ACL Injuries

Land Like a Ballerina to Avoid ACL Injury! In the United States, in over a decade, we’ve seen a greater-than 900% increase in ACL injuries in girl’s sports. Interestingly, despite this epidemic, research shows that in comparison, ballerinas rarely have ACL...
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ACL Tear Stem Cell Injection: Ultrasound vs. Fluoroscopy

ACL Stem Cell Injection US vs Fluoro There’s been a lot of controversy lately over whether an ACL Tear Stem Cell Injection can be properly performed using ultrasound. Some physicians cite a paper published in 2015 that seems to show ultrasound can get the job done,...
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Opioids Before Knee Replacement Increase Pain After Surgery

If you have knee pain that over-the-counter medications haven’t seemed to touch, your doctor may prescribe an opioid, a more powerful narcotic medication. However, if you are considering a knee replacement, a new study suggests opioids and knee replacement is a...
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Who Will Respond to an ACL Stem Cell Procedure?

This weekend, I’ve spent hours and hours poring over more than 50 before and after MRIs from patients who have received the ACL stem cell procedure we invented. This is the world’s largest collection of data to date on what happens when stem cells are...
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Knee Popping After Injury? This Could be a Bad Sign…

As you get older, some of us have joints that don’t hurt but start to make noises. Remember those cute Rice Krispies guys, Snap, Crackle, and Pop? If your knees sound like a bowl of Rice Krispies or you’re dealing with knee popping after injury, according...
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Running on Pins and Needles: Cartilage Holes in My 17-Year-Old

Several years ago, my oldest son began reporting knee pain and limping. That began a long ordeal that finally ended yesterday. Let me explain. My Son’s Knees My oldest son is named after my father. He was a premature twin that weighed 2 pounds 4 ounces and came...
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Orthopedics 2.0: How Regenerative Medicine Will Change Everything

Surgery should always be a last option, but it's often presented to patients as the only option. Download Orthopedics 2.0 and educate yourself on how everything in your body works together in concert to maintain your physical wellbeing. When a single component in this chain is damaged, it can lead to a cascade of joint, spine and connective tissue problems, resulting in chronic pain. Using the Regenexx SANS approach, Orthopedics 2.0 walks you through a series of tests and exercises that you can do on your own to better understand where your own body is struggling to maintain proper stability and alignment, explaining the possible reasons and long term implications along the way. Orthopedics 2.0 is a FREE download from our site & it's an Amazon Top Seller!

More Than 118,399 Downloads!

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